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2014 Fiscal Year Final Research Report

Drug response biomarker genes of ocular hypotensives

Research Project

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Project/Area Number 24592629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionShimane University

Principal Investigator

TANITO Masaki  島根大学, 医学部, 客員研究員 (30284037)

Co-Investigator(Kenkyū-buntansha) OHIRA Akihiro  島根大学, 医学部, 教授 (00169054)
HARA Katsunori  島根大学, 医学部, 助教 (00609323)
YASUYUKI Takai  島根大学, 医学部, 助教 (20397871)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords緑内障
Outline of Final Research Achievements

To explore the genes that responsible for prostaglandin metabolism in ocular tissue, SNP analyses by using DMET (Drug Metabolizing Enzyme and Transporter)-Chip (Affymetrix) were performed among 10 latanoprost high responder and 10 latanoprost low responder subjects.
Drug response against tafulprost and travoprost was tested in about 200 subjects by the multicenter clinical study.

Free Research Field

緑内障

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Published: 2016-06-03  

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