2014 Fiscal Year Final Research Report
| Project/Area Number |
24592651
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
SANO Kokoro 慶應義塾大学, 医学部
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 涙腺 / 涙液 / ドライアイ |
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| Outline of Final Research Achievements |
We investigated the effects of exercise on tear secretion in type 2 diabetic mice, and also investigated the effect of the adenosine monophosphate-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).
Exercise training for 8 weeks increased tear secretion volume in db/m and db/db mice. The levels of oxidative stress markers in tears were less in the exercise group than in the control group. In C57BL/6JJc1 mice, the tear secretion volumes in both the AICAR 125 mg/kg and AICAR 250 mg/kg groups were significantly larger than in the PBS group. Additionally, in db/db mice, tear secretion volume in the AICAR 125 mg/kg group was also significantly larger than in the PBS group.The results suggest that exercise may be a potential therapy to modulate tear secretion.
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| Free Research Field |
眼表面
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