Pathophysiological Analysis of Atopic Glaucoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Juntendo University
• Principal Investigator: MATSUDA Akira 順天堂大学, 医学(系)研究科(研究院), 准教授 (00312348)
• Co-Investigator(Kenkyū-buntansha): ONO Kouichi 順天堂大学, 医学部, 准教授 (10317399) ; MORI Kazuhiko 京都府立医科大学, 大学院医学研究科, 講師 (40252001)
• Co-Investigator(Renkei-kenkyūsha): NAKAE Susumu 東京大学, 医科学研究所, 准教授 (60450409)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アトピー / 緑内障 / ステロイド

Outline of Final Research Achievements

Open-angle glaucoma associated with severe atopic dermatitis (atopic glaucoma) tends to be severe and difficult to treat because of ocular surface/eye lid inflammation. Atopic glaucoma was often associated with atopic cataracts and retinal detachments. Surgical interventions are common because of advanced visual field defects and/or high intraocular pressures. Bleb-associated post-surgical infections were observed in 7 eyes. Ultrastructural analysis of trabecular meshwork tissues obtained from atopic
glaucoma patients showed abnormal accumulation of 10 to 30nm fibers in the corneoscleral meshwork.

Free Research Field

眼科学