Rapid and accurate surveillance of adenoviral conjunctivitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592662
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: FUJIMOTO Tsuguto 国立感染症研究所, その他部局等, その他 (60446771)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: サーベイランス / 検査 / 公衆衛生 / アデノウイルス / 組換え型

Outline of Final Research Achievements

Since 2007, new genotypes of HAdVs had been reported and caused outbreaks in Japan. New genotypes were mainly designed by complete genome sequence (or plural important region). In this study we used syndromic surveillances of to detect outbreaks of HAdVs, rapidly. By using plural PCR applications, rapid typing was possible from 90 ocular samples and 300 respiratory samples.
As the result, respiratory HAdVs were typed as HAdV-1 to -5, HAdV-56, and HAdV-57. Ocular HAdVs were typed as HAdV-1 to -5, HAdV-8, HAdV-11, HAdV-37, HAdV-53, HAdV-54, HAdV-56, HAdV-64, and HAdV-48 related recombinant strain. Novel HAdV-48 related recombinant strain isolated in two area. HAdV-3 was most frequently associated with outbreaks of pharyngoconjunctival fever. HAdV-4 caused respiratory infections among children.

Free Research Field

ウイルス学