2014 Fiscal Year Final Research Report
Analysis of miRNA signatures in Behcets disease patients treated with infliximab
| Project/Area Number |
24592678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KEINO Hiroshi 杏林大学, 眼科学教室, 准教授 (90328211)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 免疫 |
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| Outline of Final Research Achievements |
To determine the effect of infliximab on microRNA (miRNA) expression in peripheral blood mononuclear cells of Behcet's disease patients before and after initiation of infliximab treatment, we analyzed miRNA expression profiles in 4 patients at baseline and at 22 weeks after initiation of infliximab. Anti-TNF-α antibody therapy reduced the frequency of ocular attacks in 3 of 4 patients during 2 years of follow-up, while one patient continued to have inflammatory relapses during that time. Several miRNAs were increased or decreased in each patient. Although the expression of miRNA-144 was decreased in all 3 patients with no relapses, its expression was increased in the one patient who continued to have relapses. MiRNA-144 may represent a new biomarker for monitorings response to infliximab in the treatment of Behcet’s disease with refractory uveoretinitis.
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| Free Research Field |
ぶどう膜炎
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