2014 Fiscal Year Final Research Report
Interaction between miR-21 and TGFbeta: Role in chronic non-healing wounds
| Project/Area Number |
24592716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
|
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| Research Institution | University of Miyazaki |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 創傷治癒 / MicroRNA |
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| Outline of Final Research Achievements |
This project aimed to investigate the interaction between TGFβ1 and microRNA miR-21 in diabetic wounds, and to evaluate the role of miR-21 in diabetic wound healing. Employing mouse skin fibroblast cells, we found that TGFβ1 enhances miR-21 expression in hyperglycemic conditions. TGFβ1 effect on miR-21 was dependent on NFkB induced ROS generation. MiR-21 was found to promote cell migration towards wound area. Analysis of diabetic fibroblast cells revealed that miR-21 was downregulated in these cells.
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| Free Research Field |
医歯薬学
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