The study of the repair mechanism by neuron and glial cell after central nervous system injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592729
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Fukushima Medical University (2013-2014); Yamagata University (2012)
• Principal Investigator: ISEKI Ken 福島県立医科大学, 医学部, 教授 (70332921)
• Co-Investigator(Kenkyū-buntansha): GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: グリオーシス / 凍結脳損傷 / プロテオグリカン / 脂質代謝酵素

Outline of Final Research Achievements

Transcription factor OASIS controls the production of proteoglycan in embryonic development, whereas Olig is a key factor of glial differentiation. However, detailed repair mechanism after brain injury remains unclear. We investigated the expression pattern of these transcription factors after brain injury. Results suggest that OASIS is involved in the regulatory mechanism of non-permissive environments for axonal outgrowth and that Olig genes regulate glial differentiation. The expression pattern of the relevant molecules remained unchanged in KO mice of diacylglycerol kinase, an enzyme responsible for the control of a lipid messenger diacylglycerol.

Free Research Field

神経解剖学