Nrf2 is a novel marker of oxidative stress at acute hepatic failure.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Okayama University
• Principal Investigator: HIROKO Shimizu 岡山大学, 医学部, 客員研究員 (80423284)
• Co-Investigator(Kenkyū-buntansha): MORITA Kiyoshi 岡山大学, 医歯薬学総合研究科, 教授 (40108171) ; TAKAHASHI Toru 岡山県立大学, 保健福祉学部, 教授 (40252952) ; MORIMATSU Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (30379797)
• Research Collaborator: OMORI Emiko 岡山大学, 医歯薬学総合研究科, 技術補佐員
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 集中治療医学 / 急性肝傷害 / 酸化ストレス / Nｒｆ２ / オートファジー / ヘムオキシゲナーゼ / Ｂａｃｈ１ / 四塩化炭素

Outline of Final Research Achievements

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcriptional factor in the protection against oxidative stress. Nrf2 binds Map Recognition element (MARE) and regulates expression of antioxidant protein. In the present study, a transient and remarkable induction of Nrf2 mRNA was caused by oxidative stress in carbon tetrachloride (CCl4)-induced serious acute liver failure with phenobarbital pretreatment, a cytochrome P450 inducer. The serum ALT levels at 6 h after treatment were positively correlated with Nrf2 mRNA levels. Our findings suggest that Nrf2 mRNA expression may reflect the extent of oxidative tissue injury and it may be a novel marker of oxidative stress at acute hepatic failure.

Free Research Field

医歯薬学