Development of new therapeutic strategies for severe sepsis by blood purification therapy targeting at control of oxidative stress.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592741
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Oita University
• Principal Investigator: HIDAKA SEIGO 大分大学, 医学部, 助教 (00404385)
• Co-Investigator(Kenkyū-buntansha): KITANO Takaaki 大分大学, 医学部, 教授 (20211196) ; NOGUCHI Takayuki 大分大学, 医学部, 教授 (90156183) ; HAGIWARA Satoshi 大分大学, 医学部, 講師 (50527661)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 敗血症 / 臓器傷害 / 血液浄化療法 / 酸化ストレス / ビタミンE

Outline of Final Research Achievements

Severe sepsis can result in multiple organ dysfunction syndrome, a potentially life-threatening condition. In the process, oxidative stress was found to be a key factor of exacerbating inflammatory responses and organ injury. Although sepsis is the common cause of mortality in intensive care units, few therapies have established sufficient evidence. In the present study, we evaluated the effects of blood purification therapy targeting at inhibition of oxidative stress in a LPS-induced systemic inflammatory rat model. As a result, we showed that blood purification therapy prevented organ injury, and increased survival in our model owing to the antioxidant activity and early attenuation of inflammation associated with vitamin E-coated polysulfone membranes.

Free Research Field

麻酔学，集中治療医学