Significance of procalcitonin in sepsis-analysis of procalcitonin knockout mouse-

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Osaka Kawasaki Rehabilitation University
• Principal Investigator: NAKAMURA Misa 大阪河崎リハビリテーション大学, 公私立大学の部局等, 教授 (70285386)
• Co-Investigator(Renkei-kenkyūsha): KONO Ryohei 和歌山県立医科大学, 医学部, 助教 (70569110)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: プロカルシトニン / 敗血症 / サイトカイン / ノックアウトマウス

Outline of Final Research Achievements

The role of procalcitonin (PCT) in sepsis was investigated using PCT knockout mouse (PCT KO). However, there was no statistical difference of duration of survival between KO and wild injected of lipopolysaccharide (LPS), wild group showed a little higher survival rate than KO. And KO showed higher level of IL-6 and lower of IL-10 concentration in blood than wild. These results suggested that PCT have no effect on survival in sepsis, however reduces a condition of sepsis mediated by various cytokines.

Free Research Field

内分泌学