2015 Fiscal Year Final Research Report
Analysis of primary hematopoiesis in the adult mice
| Project/Area Number |
24592777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NONAKA Naoko 昭和大学, 歯学部, 准教授 (20307052)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 造血 / 一次造血 / ビスプォスプォネート / 髄外造血 / 肝臓 / hemal node / 骨髄 |
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| Outline of Final Research Achievements |
The treatment with nitrogen-containing bisphosphonate (NBP) and phenylhydrazine (PHZ) into mice enhanced the extramedullary hematopoiesis in the liver and induced the appearance of nuclear erythrocytes in the peripheral blood and hemal node like structure in the abdominal cavity. The gene analysis of hemoglobin showed the appearance of primary hematopoiesis in the bone marrow, liver and hemal node like structure inaddition to the secondary hematopoiesis. Our results first indicated the switch from the secondary to primary hematopoiesis in normal genomic animal model.
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| Free Research Field |
解剖学、組織学
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