The effect of SUMOylation on bone formation in mouse

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Shizuoka University (2013-2014); Matsumoto Dental University (2012)
• Principal Investigator: AKIRA Yukita 静岡大学, 教育学部, 講師 (80401214)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Hiroaki 松本歯科大学, 歯学部, 教授 (50227930) ; HOSOYA Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
• Co-Investigator(Renkei-kenkyūsha): ITO Yuzuru 産業技術総合研究所, 幹細胞工学研究センター, 研究チーム長 (30500079) ; HOSOYA Akihiro 松本歯科大学, 歯学部, 教授 (20264252)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨芽細胞分化 / SUMO化修飾 / 分化制御 / 培養細胞

Outline of Final Research Achievements

We investigated the effect of SUMOylation on BMP-induced osteoblastic differentiation using various cell lines. Inhibition of SUMOylation suppressed the osteoblastic differentiation induced by BMP treatment in the MC3T3E1 cells, which derived from mouse calvaria, while enhanced it in ST2 mouse bone marrow derived stromal cells and murine fibroblasts (C3H10T1/2 cells). This Data shows that the effect of SUMOylation on osteoblastic differentiation might change depending on degree of osteoblasts.

Free Research Field

組織学