2014 Fiscal Year Final Research Report
Functional analysis of the molecular complex in spatiotemporal regulation of protein phosphorylation.
| Project/Area Number |
24592805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
GAO Jing 九州大学, 大学院歯学研究院, 助教 (40585882)
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| Research Collaborator |
ZHANG Zhao
NAGANO Koki
WANG Daguang
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リン酸化 / 脱リン酸化 / 細胞内情報伝達 / 開口分泌 |
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| Outline of Final Research Achievements |
We have previously isolated a signaling molecule, PRIP which forms the protein complex with multiple kinases and phosphatases. In this year, we identified that (a)the C2 domains of PRIP and those of other molecules form hetero-dimers, and (b)a PRIP-interacting kinase Akt regulates exocytosis by phosphorylation of its new substrate tomosyn.
The results obtained in this study would promote understanding the mechanism how the phospho-dependent cellular signaling is spatio-temporally regulated by the complex containing multiple enzymes responsible for protein phosphorylation/de-phosphorylation.
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| Free Research Field |
医歯薬学
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