2015 Fiscal Year Final Research Report
Identification of the novel factors on the modulation of osteoclastogenesis
| Project/Area Number |
24592816
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAMI Masamichi 昭和大学, 歯学部歯科薬理学講座, 教授 (80307058)
YAMADA Atsushi 昭和大学, 歯学部口腔生化学講座, 講師 (50407558)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 破骨細胞 / 樹状細胞 / 分化 / 振り分け / 骨代謝 / RANKL / RANK / 遺伝子発現 |
|---|
| Outline of Final Research Achievements |
It is important for the elucidation of the bone diseases to investigate the novel factors and analyze the function during osteoclastogenesis. We found that signal transducers and activators of transcription (STAT) 5 is a important regulatory molecule for osteoclastogenesis. Similarly, overexpession of Batf, a member of AP-1 family, in macrophages, as osteoclast precursors, tended to fail to differentiate into osteoclasts. These results suggest that Stat5, as well as Batf may regulate osteoclastogenesis by suppressing osteoclastogenesis.
|
| Free Research Field |
骨代謝学、生理学
|
