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2014 Fiscal Year Final Research Report

Roles of cell degradation system regulation in oncogenesis of odontogenic epithleium within the intraosseous microenvironmnet

Research Project

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Project/Area Number 24592826
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

KUMAMOTO HIROYUKI  東北大学, 歯学研究科(研究院), 教授 (70215028)

Co-Investigator(Kenkyū-buntansha) MIKI Yasuhiro  東北大学, 災害科学国際研究所, 講師 (50451521)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords歯原性腫瘍 / 骨内微小環境 / 細胞分解
Outline of Final Research Achievements

Regulator molecules associated with cell proliferation and degradation as well as hypocic condition under the intraosseous microenvironment were examined in oncogenesis, cell differantiation, and progression. Growth factor receptors, EGFR and HER2-4, were expresssed in odontogenic epithelial cells, and reactivity for EGFR and HER4 was prominent. Gene alterations of these molecules were obscure. Autophagy-related molecules, ATG7, LC3, and p62, were recognized chiefly in odontogenic epithelial cells neighboring the basement membrane. Granula cell ameloblastoma showed high reactivity for these molecules. Hypoxia-related molecules, HIF-1 and CA IX, were found greater in ameloblastoma than in tooth germ, and solid type ameloblastoma showed high reactivity as compared with unicystic type ameloblastoma. Measurement of CD34-positive microvessels is in progress.

Free Research Field

医歯薬学

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Published: 2016-06-03  

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