2016 Fiscal Year Final Research Report
Strategic approach for oral cancers based on both of imaging and molecular biologic sides
| Project/Area Number |
24592838
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | MR spectroscopy / 18F-FDG / PET-CT / Dynamic MR sialography / oral cancer |
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| Outline of Final Research Achievements |
The quantity and rate of choline and citrate on MR spectroscopy could not precisely be visualized because of the rich fat components in the oral and maxillofacial region. 18F-FDG accumulation reflects the extent of dental inflammation such as periodontal- and periapical-inflammations, not dental caries. At the same time, the front intrinsic muscles of the tongue and upper and lower marginal parts of the orbicularis oris muscle were newly demonstrated as 18F-FDG-PET-positive areas in examining the oral and maxillofacial regions. After ND for oral cancers, we should pay attention to the 18F-FDG distributions in neck-related muscles including the non-surgical side as false-positive findings. Moreover, the rate of patients with 18F-FDG-PET-positive areas increased in the trapezius, sternocleidomastoid, and posterior neck muscles of the surgical and/or non-surgical sides according to the extent of ND of cervical lymph nodes.
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| Free Research Field |
歯科放射線学
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