2014 Fiscal Year Final Research Report
The roles of HDAC and transcription factors in oral cancer development
| Project/Area Number |
24592839
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 低酸素 / 低栄養 / 転写因子 / 脱アセチル化酵素 |
|---|
| Outline of Final Research Achievements |
In order to clarify the roles of surtuin in cancer cells, we examined how surtuin regulated the expression of hypoxia-induced genes, because we found that the expression of surtuin mRNA under hypoxic conditions.
We found that SIRT7 stimulated the expression of BCL6 and that SIRT7 increased the suppressive activity of transcription by BCL6.
|
| Free Research Field |
腫瘍学
|
