A development of wound protection materials having healing acceleration for an oral mucosal tissue defect.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592984
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyoto University
• Principal Investigator: FUJIMURA Kazuma 京都大学, 医学(系)研究科(研究院), 非常勤講師 (30252399)
• Co-Investigator(Kenkyū-buntansha): SONOBE Junya 京都大学, 医学研究科, 講師 (50464219) ; BESSHO Kazuhisa 京都大学, 医学研究科, 教授 (90229138)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 生体材料 / 粘膜保護材

Outline of Final Research Achievements

In the treated group (n=8), a tendency for the epithelium in a mucosal defect with a diameter of 5 mm to extend towards the center from the peripheral mucosa was observed. Approximately 2 weeks thereafter, the epithelial formation area was 12.56mm2 on average, and the scar contraction rate was approximately 36%. In the non-treated group (n=7), the epithelial formation area was on average 7.46 mm2, and the scar contraction rate was approximately 62%. With LYDEX, mucosal proliferation was faster, and mucosal defect sites were covered more quickly compared to those in the non-treated group; therefore, this suggested that this reduces the scar contraction rate. FGF-2 was added to LYDEX in a similar experimental method (n=4). Two weeks following treatment, the epithelial formation area was 15.11mm2 on average, and the scar contraction rate was 23%.

Free Research Field

口腔外科学