Establishment of a new treatment of oral stomatitis associated with cancer chemotherapy using a phytochemical

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: YOSHINO FUMIHKO 神奈川歯科大学, 歯学研究科(研究院), 准教授 (20308307)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口内炎 / ファイトケミカル / 抗酸化作用 / 化学療法 / 脂質過酸化 / 酸化ストレス

Outline of Final Research Achievements

The purpose of this study was thus to demonstrate the involvement of reactive oxygen species (ROS) and the alteration of the redox state in oral mucositis using an electron spin resonance (ESR). An oral mucositis animal model induced by treatment of 5-fluorouracil with 10% acetic acid in hamster cheek pouch. Lipid peroxidation was measured and the rate constants of the signal decay of nitroxyl compounds using in vivo L-band ESR were calculated from the signal decay curves. We established the oral mucositis animal model induced in hamster cheek pouch. An increased level of lipid peroxidation was found by measuring malondialdehyde. The decay rate constants of carbamoyl-PROXYL were decreased. These disorders was inhibited by treatment of alpha-glucosyl-hesperidine. These results suggest that a redox imbalance might occur by excessive generation of ROS at an early stage of oral mucositis and the consumption of large quantities of antioxidants in the locality of oral mucositis.

Free Research Field

薬理学