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2015 Fiscal Year Final Research Report

Pain have a correlation with Depression~Relevance of NPY~

Research Project

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Project/Area Number 24593052
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

Tsurumaki Tatsuru  新潟大学, 医歯学系, 助教 (10345522)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Hiroyuki  新潟大学, 医歯学総合病院, 医員 (20547575)
SEO Kenji  新潟大学, 医歯学系, 教授 (40242440)
Project Period (FY) 2012-04-01 – 2016-03-31
Keywords神経ペプチド
Outline of Final Research Achievements

I developed a trigeminal neuropathic pain model in which the withdrawal threshold to mechanical stimulation of whisker pad was significantly decreased after inferior alveolar nerve injury. Therefore, I performed experiments to examine neuropeptide Y and its receptors (Y1, Y2, Y4 and Y5) expression using this neuropathic pain model. Expression of neuropeptide Y mRNA was significantly increased after inferior alveolar nerve injury. The expressions of neuropeptide Y receptors were also changed after inferior alveolar nerve injury.

Free Research Field

歯科麻酔学

URL: 

Published: 2017-05-10  

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