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2014 Fiscal Year Final Research Report

Involvement of the Warburg effect in the regulation of ccn2 gene expression

Research Project

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Project/Area Number 24593060
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionShowa University

Principal Investigator

KONDO Seiji  昭和大学, 歯学部, 准教授 (10432634)

Co-Investigator(Kenkyū-buntansha) KAMATANI Takaaki  昭和大学, 歯学部, 助教 (00315003)
MUKUDAI Yoshiki  昭和大学, 歯学部, 助教 (50325099)
KURIHARA Yuji  昭和大学, 歯学部, 助教 (90514969)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords低酸素
Outline of Final Research Achievements

A novel GAPDH-mediated gene regulatory mechanism controlling the stability of ccn2 mRNA during hypoxia is uncovered. The precise regulatory mechanism of the degradation of ccn2 mRNA by the interaction among the ccn2 3'-UTR and GAPDH was identified. The observed redox regulation would supposedly be important for switching ccn2 gene expression upon the exposure to hypoxic or oxidative stress.

Free Research Field

口腔外科

URL: 

Published: 2016-06-03  

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