Studies on the mechanisms of noradrenaline and dopamine release in the nucleus accumbens

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: TAKADA Koji 日本大学, 歯学部, 講師 (00216657)
• Co-Investigator(Kenkyū-buntansha): SAIGUSA Tadashi 日本大学, 歯学部, 教授 (50277456)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔ジスキネジア / ノルアドレナリン / ドパミン / アドレナリン受容体 / ラット

Outline of Final Research Achievements

Oral dyskinesia is a neurological disorder is characterized by involuntary repetitive orofacial movement. It is associated with aging or use of drugs for Parkinson’s disease and antipsychotics. The detailed biological basis of the syndrome is unclear, but the pharmaco-behavioural studies indicate that enhance of dopamine function in the nucleus accumbens and striatum plays major role for the induction of repetitive jaw movements of rats. In the present study, we investigated the roles of adrenaline receptor subtypes in the regulation of accumbal dopaminergic activity in freely moving rats, using the in vivo brain microdialysis technique.

Free Research Field

歯科麻酔