2014 Fiscal Year Final Research Report
Development of new dental treatment stress reduction method from the brain neural network mechanism
| Project/Area Number |
24593068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Yukie 久留米大学, 医学部, 講師 (10279135)
ABE Keiko 鶴見大学, 歯学部, 講師 (30401334)
HARANO Nozomu 九州歯科大学, 歯学部, 助教 (50423976)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ストレス / 神経科学 / 脳・神経 / 薬理学 / 歯学 / 精神鎮静法 / 抗不安薬 / マイクロダイアリシス |
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| Outline of Final Research Achievements |
We studied effects of the acute stress on neural activity in the rat brain.
The actions of the anxiolytis and sedatives on the central nervous system have been studied by microdialysis. This approach has shown that anxiolytis and sedatives suppress the accentuation of the locus coeruleus - medial prefrontal cortex neural activity, the accentuation of the ventral tegmental area - nucleus accumbens neuron activity, and the accentuation of the raphe - amygdala neuron activity in the stress state.
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| Free Research Field |
歯科麻酔学
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