2014 Fiscal Year Final Research Report
Effect of bone microenvironment factors on bone healing
| Project/Area Number |
24593069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
URADE Masahiro 兵庫医科大学, 医学部, 特別招聘教授 (70104883)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 骨代謝 / 顎骨壊死 / TGF-β |
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| Outline of Final Research Achievements |
We evaluated the side effects of bisphosphonates on extraction socket healing in spontaneously diabetic Torii (SDT) rats, which is an established model of non-obese type 2 diabetes mellitus in study of bone microenvironment. We demonstrated the development of BRONJ-like lesions and suggested that low bone turnover with less inflammatory cell infiltration plays an important role in the development of BRONJ. The aim of this study was to determine the effects of TGF-β1 on migration of OC precursors (OPs) in the bone microenvironment. The round shape of RAW cells changed into a spindle shape by treatment with TGF-β1. The cell migration of RAW cells was decreased by treatment with TGF-β1. We showed that TGF-β1 is released from the bone matrix induces motile OPs to quiescent OPs in bone microenvironment.
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| Free Research Field |
口腔外科
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