Molecular analysis in developmental defects of teeth by viral infection

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: MONMA Yuko 東北大学, 加齢医学研究所, 非常勤講師 (00191073)
• Co-Investigator(Kenkyū-buntansha): OGASAWARA Koetsu 東北大学, 加齢医学研究所, 教授 (30323603)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 感染症

Outline of Final Research Achievements

On epidemiological studies, it has been reported that the hypoplasia of the teeth is affected by the virus infection. In this study, we investigated that the effect on the formation of a tooth by viral infection in view of the inflammatory responses. We found that inflammatory cytokines were increased in the culture supernatant, when mouse monolayer cells were infected with the herpes family viruses in vitro. Inflammatory cytokines such as IFN and IL-1 were produced by immune cells at initial infection phase and then, fibroblasts which are present around the tooth precursor cells, are affected by these cytokines. These results suggested that the formation of a tooth may be influenced by inflammatory cytokines from immune cells.

Free Research Field

医歯薬学