Maternal occlusal disharmony produces the learning deficits by the altered hippocampal neurogenesis, enriched enviroment of pups ameliorates the learning deficits

2015 Fiscal Year Final Research Report

• Project/Area Number: 24593113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Asahi University
• Principal Investigator: Iinuma Mitsuo 朝日大学, 歯学部, 教授 (70184364)
• Co-Investigator(Kenkyū-buntansha): KUBO Kin-ya 星城大学, リハビリテーション学部, 教授 (00329492) ; TAMURA Yasuo 朝日大学, 歯学部, 教授 (40113047)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 妊娠中の咬合障害 / 仔マウス / 飼育環境良好 / 海馬機能 / 空間認知能

Outline of Final Research Achievements

To determine which aspect of neurogenesis regulation is influenced in the hippocampus of pups obtained from dams in the bite-raised condition during pregnancy, we examined the proliferation of newborn cells in the pup hippocampus and spatial learning ability.
Plasma corticosterone levels of bite-raised group in dam were greater than those of the control group. The dams of maternal bite-raised condition was decreased the proliferation of newborn cells in the pup hippocampus and spatial learning ability. Exposure to an enriched environment enhances, hippocampal cell proliferation and spatial learning ability were improved.

Free Research Field

小児歯科学