Investigating the Alveolar Bone-Loss Mechanism in Elderly Women, using Ovariectomized Monkey Subjects with Ligature-Induced Periodontitis.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593133
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Asahi University
• Principal Investigator: EJIRI Sadakazu 朝日大学, 歯学部, 教授 (40160361)
• Co-Investigator(Kenkyū-buntansha): TANAKA Mikako 新潟大学, 医歯学総合病院, 講師 (20361909) ; SIBUTANI Toshiaki 朝日大学, 歯学部, 教授 (40206149) ; KOGAYA Yasutoku 朝日大学, 歯学部, 准教授 (30076046) ; SATOU Kazuhiko 朝日大学, 歯学部, 講師 (20340078) ; WATANABE Ryuuta 朝日大学, 歯学部, 助教
• Co-Investigator(Renkei-kenkyūsha): MIKAMI Emi 新潟大学, 医歯学総合病院, 医員 (20149328)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨粗鬆症 / 卵巣摘出モデル / 歯槽骨 / 歯周炎

Outline of Final Research Achievements

In order to elucidate the relationship between post-menopausal osteoporosis and periodontitis, as involved in the mechanism of alveolar bone loss in elderly women, our study investigated microstructural alveolar bone changes occurring in ovariectomized monkeys with and without ligature-induced periodontitis, and also examined the effects of Cathepsin K inhibitor as an anti-bone loss agent in these animals.
Our findings suggest that the local inflammation induced by periodontitis, together with systemic hormonal changes such as estrogen deficiency, may synergistically accelerate alveolar bone loss in elderly women. Furthermore, the results suggest that Cathepsin K inhibitor may also be useful for suppressing bone loss and accelerating alveolar bone formation in elderly women.

Free Research Field

口腔解剖学