Anti-aging effects of ubiquinol on oral tissues

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593153
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: TOMOFUJI Takaaki 岡山大学, 大学病院, 講師 (80335629)
• Co-Investigator(Kenkyū-buntansha): MORITA Manabu 岡山大学, 医歯(薬)学総合研究科, 教授 (40157904) ; EKUNI Daisuke 岡山大学, 大学病院, 講師 (70346443) ; AZUMA Tetsuji 岡山大学, 医歯(薬)学総合研究科, 助教 (80432649)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 抗加齢 / ユビキノール

Outline of Final Research Achievements

Oxidative stress is associated with aging of the periodontal tissue. The anti-oxidative effects of a reduced form of co-enzyme Q10 (ubiquinol) may affect periodontal tissue aging. We examined the effects of topically applied ubiquinol on periodontal tissue aging in a rat model. Male Fischer 344 rats received topically applied ointment with or without 1% ubiquinol on the gingival surface until they reached 6 mos of age. Ubiquinol decreased oxidative DNA damage and tartrate-resistant acid-phosphatase-positive osteoclasts in the periodontal tissue as compared with the control. The results indicate that topical application of ubiquinol could suppress age-related osteoclast differentiation by inhibiting oxidative stress.

Free Research Field

予防歯科学