Prevention of cancer by oral care inhibiting the production of acetaldehyde

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593154
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: YOKOI AYA 岡山大学, 大学病院, 医員 (00612649)
• Co-Investigator(Kenkyū-buntansha): YAMANAKA Reiko 岡山大学, 大学病院, 助教 (00379760) ; MORITA Manabu 岡山大学, 医歯(薬)学総合研究科, 教授 (40157904) ; YAMASAKI Yutaka 北海道大学, 歯学研究科(研究院), 教授 (90250464) ; KASHIWAZAKI Haruhiko 北海道大学, 大学病院, 講師 (10344516) ; HATA Hironobu 北海道大学, 歯学研究科(研究院), 助教 (70450830)
• Co-Investigator(Renkei-kenkyūsha): TOMOFUJI Takaaki 岡山大学, 医歯(薬)学総合研究科, 准教授 (80335629) ; TAMAKI Naofumi 徳島大学, 大学院医歯薬学研究部, 准教授 (20335615) ; EKUNI Daisuke 岡山大学, 大学病院, 講師 (70346443) ; MARUYAMA Takayuki 岡山大学, 大学病院, 助教 (30580253) ; SOGA Yoshihiko 岡山大学, 大学病院, 准教授 (70509489)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔ケア / アセトアルデヒド / 舌苔 / 上部消化管癌

Outline of Final Research Achievements

The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and tongue coating volume in healthy volunteers. Acetaldehyde concentration in participants with a tongue coating score of 3 was significantly higher than those with a score of 1. After removing tongue coating, acetaldehyde concentration was significantly decreased.
Oral microflora on the tongue may be the main source of local production of acetaldehyde. Removing tongue coating may be a method inhibiting the production of acetaldehyde.

Free Research Field

社会系歯学