• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Study of a disintegrin and metalloproteases for prevention and treatment of periodontal diseases

Research Project

  • PDF
Project/Area Number 24593163
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

AWANO Shuji  九州歯科大学, 歯学部, 教授 (20301442)

Co-Investigator(Kenkyū-buntansha) SOH Inho  九州歯科大学, 歯学部, 講師 (10285463)
YOSHIDA Akihiro  松本歯科大学, 歯学部, 教授 (20364151)
ANSAI Toshihiro  九州歯科大学, 歯学部, 教授 (80244789)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsADAM17 / 歯周病 / 歯周組織 / 口腔ケラチノサイト / TNFα
Outline of Final Research Achievements

The aim of this study was to verify the possibility of a disintegrin and metalloproteinases (ADAMs), which was a family of peptidase proteins, as a target for treatment and prevention of periodontal diseases. In this study, ADAM17, which was an important enzyme of ADAMs, was focused, and it was evident that ADAM17 was prevalent in the epithelial cells of periodontal tissue. Additionally, this study showed that the levels of expression of ADAM17 and TNFα , which was a inflammatory cytokine, from the cultured oral epithelial cells and squamous cell carcinoma were enhanced by the stimulation of bacterial LPS originated form P. gingivalis, which was a pathogenic bacteria of periodontitis, and E.coli, and that there was a significant correlation between the expression of the ADAM17 and the TNFα. Thus, this study suggested that ADAM17 might be associated with the production of TNFα in gingival epithelial cells,

Free Research Field

予防歯科

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi