Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593348
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Lifelong developmental nursing
• Research Institution: Sapporo Medical University
• Principal Investigator: EBINA Satoko 札幌医科大学, 保健医療学部, 講師 (50583738)
• Co-Investigator(Kenkyū-buntansha): KASHIWAKURA Ikuo 弘前大学, 大学院保健学研究科, 教授 (00177370)
• Co-Investigator(Renkei-kenkyūsha): MONZEN Satoru 弘前大学, 大学院保健学研究科, 助教 (20514136) ; NISHINO Kayoko 青森中央学院大学, 准教授 (70091626)
• Research Collaborator: OZAKI Takashi ; YAMAGUCHI Masaru
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 臍帯血 / 胎児 / 8-OHdG / 酸化ストレス

Outline of Final Research Achievements

In the present study, to clarify the involvement of 8-OHdG contained in placental/umbilical cord blood (CB) during the perinatal period, the relationships between the levels of CB 8-OHdG and maternal/neonatal characteristics in vaginal deliveries were determined. The 8-OHdG levels in CB ranged from 0.1 to 1.39 ng/mL (median, 0.37 ng/mL). The 8-OHdG level detected in the nonsmoking group was significantly lower than that in the smoking group. However, no significant correlation was observed between 8-OHdG levels and other maternal/neonatal factors, including umbilical artery acid/base and gas values. In addition, significant positive correlations were observed between 8-OHdG levels and both placental weight and placental weight per infant birth weight (r = 0.343, p = 0.007; r = 0.368, p = 0.004, respectively). However, no significant correlations were observed between the 8-OHdG levels and infant birth weight.

Free Research Field

医歯薬学