2014 Fiscal Year Final Research Report
Novel functions of surface and intracellular muscarinic receptors in central nervous system and stress
| Project/Area Number |
24600006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
子ども学(子ども環境学)
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| Research Institution | Kanazawa Medical University (2014)
University of Fukui (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMUNE Atsushi 福井大学, 医学部, 助教 (40311310)
UWADA Jyunsuke 旭川医科大学, 医学部, 助教 (70580314)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ムスカリン受容体 / アセチルコリン / 記憶 / ストレス |
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| Outline of Final Research Achievements |
M1-muscarinic acetylcholine receptors (mAChRs) exist not only on cell surface but also at intracellular sites in the cerebral cortex and hippocampus. ACh acts on surface and intracellular mAChRs and activates distinct signaling pathways, involving in cholinergic facilitation of long-term potentiation in hippocampus. Stress selectively inhibits the expression of intracellular M1-mAChRs in cerebral cortez and hippocampus, probably leading the redunction of higher brain functions. The present results suggest cholinergic dual transmission in central nervous system and may give a significant clue to explore higher brain functions.
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| Free Research Field |
薬理学
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