2014 Fiscal Year Final Research Report
Establishment of plasma neutrophil gelatinase associated lipocalin level as a biomarker in endothelial dysfunction and renal dysfunction in the early stage in patients with obstructive sleep apnea
| Project/Area Number |
24621005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
睡眠科学
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| Research Institution | Kyushu University (2013-2014)
Kyoto University (2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Kiyoshi 京都大学, 大学院医学研究科, 准教授 (60343232)
CHIN Kazuo 京都大学, 大学院医学研究科, 特定教授 (90197640)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 睡眠時無呼吸 / Ngal / 腎障害 / バイオマーカー |
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| Outline of Final Research Achievements |
Obstructive sleep apnea (OSA) and a novel lipocalin, neutrophil gelatinase associated lipocalin (Ngal),have been reported to be closely linked with cardiovascular disease and loss of kidney function through chronic inflammation. However, the relationship between OSA and Ngal has never been investigated. In 102 patients, plasma Ngal levels were measured. Ngal levels were reevaluated after three months of treatment in 25 patients.The Ngal level correlated significantly with OSA severity as determined by the apnea hypopnea index and 4% oxygen desaturation index (ODI). Multiple regression analysis showed that the Ngal level was associated with 4%ODI independently of other clinical variables. The Ngal levels were not significantly changed after CPAP.Plasma Ngal levels were positively associated with the severity of OSA. However, it does not seem reasonable to use the Ngal level as a specific biomarker of OSA in clinical practice.
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| Free Research Field |
睡眠学
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