Understanding of the in vivo temporal patterns of insulin

2013 Fiscal Year Final Research Report

• Project/Area Number: 24650153
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Bioinformatics/Life informatics
• Research Institution: The University of Tokyo
• Principal Investigator: KUBOTA Hiroyuki 東京大学, 理学(系)研究科(研究院), 研究員 (40376603)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: インスリン / 時間パターン / システム生物学

Research Abstract

It is reported that temporal patterns of blood insulin are important for physiological homeostasis. We revealed that the importance of temporal patterns of insulin using cultured cells, however, the importance in our body remains unknown. In this proposal, as a "Challenging Exploratory Research", we established an experimental system to stimulate rats by a direct insulin injection. As results, we can stimulate rats under conditions of (i) a somatostatine injection via jugular vein to suppress the endogenous insulin release, (ii) a glucose injection via jugular vein to maintain blood glucose level and (iii) an insulin injection via mesenteric vein.