2014 Fiscal Year Final Research Report
Postnatal brain development regulated by intellectual disability-associated protein complex
| Project/Area Number |
24650199
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 精神遅滞 / DEAF1 / 複合体 / FMRP / 分子シグナル |
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| Outline of Final Research Achievements |
We analyzed the expression patterns of intellectual disability-associated protein DEAF1 in the postnatal period of wild-type mouse brain. Immunofluorescence study revealed that DEAF1 was highly expressed in the neuronal dendrites of cerebral cortex and hippocampus. Commercially available antibodies were not able to enrich DEAF1 in the immunoprecipitation assays using the mouse brain extracts. Thus DEAF1-FMRP complex was not detected in this study. Knockdown and overexpression of DEAF1 in Neuro2a cells suggested that DEAF1 is involved in the process for extension of dendrites. We are currently investigating the molecular mechanisms underlying these neuronal phenotypes.
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| Free Research Field |
小児神経学
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