2012 Fiscal Year Final Research Report
Development of a next-generation photo-stimulation device
Project/Area Number |
24650214
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Fusional basic brain science
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Research Institution | Saitama University |
Principal Investigator |
NAKAI Junichi 埼玉大学, 脳科学融合研究センター, 教授 (80237198)
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Co-Investigator(Renkei-kenkyūsha) |
ANDO Keiko 埼玉大学, 脳科学融合研究センター, 特任 准教授 (40221741)
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Research Collaborator |
OHKURA Masamichi 埼玉大学, 脳科学融合研究センター, 准教授 (70369172)
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Project Period (FY) |
2012
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Keywords | 光遺伝学 / オプトジェネティクス / 第二高調波 / 極超短赤外線パルスレーザー / KTN 結晶 |
Research Abstract |
In this study we developed a microscope equipment with which photosensitive molecules can be stimulated. In the equipment a pair of potassium tantalate niobate (KTN) crystals were used as a tunable lens, an electro-optic device that changes its refractive index by voltage. By changing the voltage which applied to the tunable KTN lens focus changed within ~23 microseconds. The speed of focus change was about 500~1000 times faster than that of the conventional piezo focuser. This technique can be applicable not only to scientific researches including neuroscience but also industrial field such as laser processing.
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Research Products
(26 results)
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[Journal Article] Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd22012
Author(s)
Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, BeloJA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H
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Journal Title
Science
Volume: 338
Pages: 226-231
DOI
Peer Reviewed
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[Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012
Author(s)
Tanaka KF, Matsui K, Sasaki T, Sano H, Sugio S, Fan K, Hen R, Nakai J, Yanagawa Y, Hasuwa H, Okabe M, Deisseroth K, Ikenaka K, Yamanaka A
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Journal Title
Cell Rep
Volume: 2
Pages: 397-406
DOI
Peer Reviewed
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[Remarks] 報道関連情報(1)Kawabata I, Kashiwagi I, Obashi K, Ohkura M, Nakai J, Wynshaw-Boris A, Yanagawa Y and Okabe S:Moving synapses on developing neurons. Nature 姉妹誌注目のハイライト、2012 年3月7日.
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[Remarks] (2)日経産業新聞: Muto A, Ohkura M et al, CurrentBiology 23, 1-5, 2013の論文に関 る記事が掲載された。内容:脳活動生きたまま観察.報道年月日:H25.2.13
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[Remarks] Muto A, Ohkura M et al, Current Biology 23,1-5, 2013 の論文が国内外のインターネット サイト(以下)に大きく取り上げられた。
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[Remarks] (3)大倉正道:蛍光分子センサーの開発と神経回路研究への応用.日本経団連埼玉埼経協ニュース371,18-18,(2012).