2014 Fiscal Year Final Research Report
Study on abnormal behavior induced by cytokine administration in nonhuman primates.-An attempt to produce a monkey model of schizophrenia-
| Project/Area Number |
24650215
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Fusional basic brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAWA Hiroyuki 新潟大学, 脳研究所, 教授 (50183083)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | コモンマーモセット / アカゲザル / EGF / 認知機能障害 / 統合失調症 / サイトカイン / 新生児 |
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| Outline of Final Research Achievements |
In the present study, we investigated whether abnormal behavior could be induced by administration of cytokine in monkeys. A common marmoset monkey subcutaneously injected EGF showed hyper activity, abnormal eye movement, and a learning deficit indicating hypofrontality. Our data suggest that perinatal exposure to cytokine can be a cause of mental disorders.
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| Free Research Field |
認知神経科学
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