2013 Fiscal Year Final Research Report
Development of anticancer therapy by painless vaccination
| Project/Area Number |
24650284
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASAKI Nagasaki 筑波大学, 数理物質科学研究科, 教授 (90198309)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 薬物送達システム / イオントフォレシス / 癌ワクチン |
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| Research Abstract |
In this study, we attempted to develop a novel anticancer immunotherapeutic system, which can induce effective immune response by noninvasive delivery of antigen peptide to Langerhans cells via combination of iontophoresis and nanoparticles. As the results, specific delivery of antigen peptide to epidermal region was successfully achieved by iontophoresis of cationic PEGylated nanogels modified with human melanoma antigen peptide hgp100(25-33), and activation of Langerhans cells in the skin was accomplished by iontophoresis of antige peptide/nanogel complexes. Moreover, we succeeded in the significant inhibition of tumor growth in melanoma bearing mice by iontophoresis of antigen/nanogel complexes.
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