2013 Fiscal Year Final Research Report
Development of new bubble with fluorous chemistry
| Project/Area Number |
24650299
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | マイクロバブル / 超音波 / セラノスティクス |
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| Research Abstract |
C3F8 encapsulated bubble liposome was developed under fluoras-chemistry. Liposome was prepared with F-palmitoyl phosphatidylcholine (F-DPPC, 2F-DPPC), DSPC and DSPE-PEG2000-OMe, and C3F8 was encapsulated to make bubble liposome. The presence of F-DPPC increased C3F8 encapsulation rate. To aim at the practical use of bubble liposome, freeze dry formulation of bubble liposome was examined. Rehydration of freeze dried bubble liposome showed same property of bubble liposome in size, ultrasound imaging and cavitation.
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