2013 Fiscal Year Final Research Report

Exploration of the preventive effects of diet on cancer metastasis

Research Project

Project/Area Number	24650504
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Eating habits, studies on eating habits
Research Institution	Kagawa Nutrition University
Principal Investigator	HIRAISHI Sayuri 女子栄養大学, 栄養科学研究所, 講師 (20150659)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	栄養学 / 概日リズム / 癌転移 / 食生活
Research Abstract	The expression of clock genes that modulate circadian rhythms rises and falls over a 24-h period. Feeding mice during the daytime when they normally rest led to a shift in the peak expression time of clock genes and significantly promoted cancer metastasis. Moreover, compared with wild-type mice, the number of metastatic nodules was significantly increased in the lungs of Clock mutant mice with abnormalities in CLOCK protein function, indicating that disruptions in circadian rhythm promoted cancer metastasis. Prolonging abnormal feeding times also appeared to increase the mRNA expression of both P-selectin and Vcam-1 adhesion molecules in the lungs. These findings suggest that the inability to maintain a regular meal time may disrupt the circadian rhythms of circadian clock genes and affect expression of some adhesion molecules, thereby promoting cancer metastasis.

(4 results)