The establishment of synthetic design guide for emission maximum of luciferin analogue

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650633
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnosis
• Research Institution: The University of Electro-Communications
• Principal Investigator: MAKI Shojiro 電気通信大学, 情報理工学(系)研究科, 助教 (20266349)
• Co-Investigator(Kenkyū-buntansha): NIWA Haruki 電気通信大学, 大学院情報理工学研究科, 教授 (20135297)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 近赤外発光 / ルシフェリン / ルシフェラーゼ / ホタル生物発光 / インビボイメージング / 有機合成 / 人為制御 / 指標

Outline of Final Research Achievements

We have reached a goal innovating new luciferin analogue having 700nm emission maximum. Besides, we have found emission maximum control method for “NIR luciferin Aka Lumine” by replacing just one atom from C to N, on aromatic site of “NIR luciferin Aka Lumine”.
When the C5 position on the aromatic site of “Aka Lumine” replaced, the emission maximum has been blue shift ca. 50nm. However, when the C2 position on the aromatic site of “Aka Lumine” replaced, the emission maximum has been not shifted.

Free Research Field

生物有機化学