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2013 Fiscal Year Final Research Report

An attempt to develop novel anti-cancer agents through fusion of the cancer stem cell hypothesis and mitochondrial metabolism study

Research Project

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Project/Area Number 24650644
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Clinical oncology
Research InstitutionYamagata University

Principal Investigator

SEINO Shizuka  山形大学, 医学部, 助手 (80571653)

Co-Investigator(Renkei-kenkyūsha) SATO Atsushi  山形大学, 医学部, 助教 (30455901)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords抗がん物質探索
Research Abstract

The aim of this project is to test the working hypothesis that Warburg effect plays a critical role in the maintenance of cancer stem cells in various intractable human cancers including malignant brain tumors. The results of a series of experiments revealed that a compound with a mitochondrial respiration-promoting effect inhibits the stemness of cancer stem cells derived from intractable human cancers including malignant brain tumors. The results suggest the possibility that Warburg effect may represent a potential target for cancer stem cell-directed therapy.

  • Research Products

    (7 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (1 results)

  • [Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression2014

    • Author(s)
      Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C
    • Journal Title

      Int J Oncol

      Volume: 44 Pages: 591-599

    • Peer Reviewed
  • [Journal Article] Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells2014

    • Author(s)
      Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Narita Y, Shibui S, Kayama T, Kitanaka C
    • Journal Title

      Stem Cell Res

      Volume: 12 Pages: 119-131

    • Peer Reviewed
  • [Journal Article] Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells2013

    • Author(s)
      Okada M, Shibuya K, Sato A, Seino S, Watanabe E, Suzuki S, Seino M, Kitanaka C
    • Journal Title

      Oncol Rep

      Volume: 30 Pages: 1957-1964

    • Peer Reviewed
  • [Journal Article] Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells2013

    • Author(s)
      Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
    • Journal Title

      Stem Cell Res

      Volume: 11 Pages: 601-610

    • Peer Reviewed
  • [Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012

    • Author(s)
      Sato A, Sunayama J, Okada M, Watanabe E, Seino S, Shibuya K, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
    • Journal Title

      Stem Cells Transl Med

      Volume: 1 Pages: 811-824

    • Peer Reviewed
  • [Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012

    • Author(s)
      Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
    • Journal Title

      Sci Rep

      Volume: 2 Pages: 516

    • Peer Reviewed
  • [Presentation] レスベラトロールによるNanog-p53経路を介したグリオーマ幹細胞の制御2013

    • Author(s)
      佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正
    • Organizer
      第14回日本分子脳神経外科学会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2013-10-19

URL: 

Published: 2015-06-25  

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