2013 Fiscal Year Final Research Report
Analysis of Cenp-A and HJURP at damage sites
| Project/Area Number |
24651047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | Cenp-A / クロマチン / プロテアソーム |
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| Research Abstract |
It has been reported that Cenp-A, a centromere-specific histone, is also found transiently at DNA damage sites.We isolated a mutant, rpt3-1, in which distribution of Cenp-A is abnormal. Interestingly, the mutant is sensitive to DNA damaging agent.These results would suggest that Rpt3 is responsible for removal of Cenp-A from chromatin at proper timing. A part of these results will be published in Nature Communications.
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