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2013 Fiscal Year Final Research Report

Protective effects of hydrogen against irradiation

Research Project

  • PDF
Project/Area Number 24651055
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNippon Medical School

Principal Investigator

OHTA Shigeo  日本医科大学, 医学(系)研究科(研究院), 教授 (00125832)

Co-Investigator(Renkei-kenkyūsha) KAMIMURA Naomi  日本医科大学, 老人病研究所生化学部門, 准教授 (60283800)
WOLF Alexander  日本医科大学, 老人病研究所生化学部門, 講師 (20434136)
NISHIMAKI Kiyomi  日本医科大学, 老人病研究所生化学部門, マネジメントスタッフ (00465345)
ICHIMIYA Harumi  日本医科大学, 老人病研究所生化学部門, アシスタントサポートスタッフ (40553251)
YOKOTA Takashi  日本医科大学, 老人病研究所分子生物学部門, マネジメントスタッフ (30445829)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords損傷 / 水素分子 / 抗酸化物質
Research Abstract

Ionizing irradiation produces free radicals such as hydroxyl radical (•OH) by reacting with water. Then, these free radicals act as a trigger for initiating the free radical chain reaction, resulting in the generation of lipid peroxides, which cause the damages in cells. The author has shown that molecular hydrogen (H2) reacts with •OH to protect cells. Moreover, H2 protects cells, organs and mice against irradiation. This study revealed that a low concentration (~0.08 mM) of molecular hydrogen (H2) terminates the free radical chain reaction to prevent lipid peroxides and to protect cells. The author would like to direct that this study is valuable as a basic investigation, but insufficient for the actual application in public.

  • Research Products

    (49 results)

All 2014 2013 2012 2011 2006 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (20 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] Real-Time Monitoring of Oxidative Stress in Live Mouse Skin2014

    • Author(s)
      Wolf AM, Nishimaki K, Kamimura N, Ohta S
    • Journal Title

      J Invest Dermatol

      Volume: 34(6) Pages: 1701-1709

    • DOI

      10.1038/jid.2013.428

    • Peer Reviewed
  • [Journal Article] Regular Moderate or Intense Exercise Prevents Depression-Like Behavior without Change of Hippocampal Tryptophan Content in Chronically Tryptophan-Deficient and Stressed Mice2013

    • Author(s)
      Lee H, Ohno M, Ohta S, Mikami T
    • Journal Title

      PLoS One

      Volume: 8(7) Pages: e66996

    • DOI

      10.1371/journal.pone.0066996

    • Peer Reviewed
  • [Journal Article] Pilot study of H2 therapy in Parkinson's disease : A randomized double-blind placebo-controlled trial2013

    • Author(s)
      Takahashi M, Wolf AM, Watari E, Norose Y, Ohta S, Takahashi H
    • Journal Title

      Mov Disord

      Volume: 28(6) Pages: 836-839

    • DOI

      10.1016/j.antiviral.2013.06.016

    • Peer Reviewed
  • [Journal Article] Haploinsufficiency of akt1 prolongs the lifespan of mice2013

    • Author(s)
      Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T
    • Journal Title

      PLoS One

      Volume: 8(7) Pages: e69178

    • DOI

      10.1371/journal.pone.0069178

    • Peer Reviewed
  • [Journal Article] Intense exercise enhances the hippocampal proliferation of progenitor cells via activating the Flk1 signaling cascade in mice2013

    • Author(s)
      Lee H, Kiuchi T, Muto J, Ohta S, Mikami T
    • Journal Title

      GAZZETA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE A Journal on Internal Medicine and Pharmacology

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] 3271番位tRNA^<lue(uur)>変異を有するミトコンドリア糖尿病の15年を超えた追跡経過観察2013

    • Author(s)
      鈴木吉彦、島田朗、佐野元昭、太田成男
    • Journal Title

      糖尿病学会誌査

      Volume: 56(3) Pages: 173-8

    • URL

      https://www.jstage.jst.go.jp/browse/tonyobyo/56/3/_contents/-char/ja/

    • Peer Reviewed
  • [Journal Article] H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia2012

    • Author(s)
      Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, Kawamura A, Abe T, Ohta S, Fukuda K, Hori S
    • Journal Title

      J. Am. Heart Assoc

      Volume: 1(5) Pages: e003459

    • DOI

      10.1161/JAHA.112.003459

    • Peer Reviewed
  • [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis2012

    • Author(s)
      Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K,(他21名)
    • Journal Title

      J. Bone Miner Res

      Volume: 27(9) Pages: 2015-2023

    • DOI

      10.1002/jbmr.1634

    • Peer Reviewed
  • [Journal Article] Taurine ameliorates impaired mitochondrial function and prevents stroke-like episodes in patients with MELAS2012

    • Author(s)
      Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y
    • Journal Title

      Intern. Med.

      Volume: 51(24) Pages: 3351-3357

    • URL

      https://www.jstage.jst.go.jp/article/internalmedicine/51/24/51_51.7529/_pdf

    • Peer Reviewed
  • [Journal Article] Biochemistry of mitochondria, life and intervention 20102012

    • Author(s)
      Koga Y, Tanaka M, Ohta S, Wei YH
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820(5) Pages: 551-552

    • DOI

      10.1016/j.bbagen.2012.01.008

    • Peer Reviewed
  • [Journal Article] Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity2012

    • Author(s)
      Kashio A, Sakamoto T, Kakigi A, Suzuki M, Suzukawa K, Kondo K, Sato Y, Asoh S, Ohta S, Yamasoba T
    • Journal Title

      Gene Ther

      Volume: 19(12) Pages: 1141-1149

    • DOI

      10.1038/gt.2011.204

    • Peer Reviewed
  • [Journal Article] Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model2012

    • Author(s)
      Sakurazawa M, Katsura K, Saito M, Asoh S, Ohta S, Katayama Y
    • Journal Title

      Brain Res

      Volume: 1430 Pages: 86-92

    • DOI

      10.1016/j.brainres.2011.10.041

    • Peer Reviewed
  • [Journal Article] Improvement of the post-thaw qualities of Okinawan native Agu pig sperm frozen in an extender supplemented with antiapoptotic PTD-FNK protein2012

    • Author(s)
      Shimokawa K, Oshiro R, Yamanaka K, Ashizawa K, Ohta S, Tatemoto H
    • Journal Title

      Theriogenology

      Volume: 78(7) Pages: 1446-1455

    • DOI

      10.1016/j.theriogenology.2012.06.005

    • Peer Reviewed
  • [Journal Article] Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases2012

    • Author(s)
      Ohta S
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820(5) Pages: 586-594

    • DOI

      10.1016/j.bbagen.2011.05.006

    • Peer Reviewed
  • [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice2011

    • Author(s)
      Kamimura N, Nishimaki K, Ohsawa I. Ohta S
    • Journal Title

      Obesity (Silver Spring)

      Volume: 19(7) Pages: 1396-1403

    • DOI

      10.1038/oby.2011.6

    • Peer Reviewed
  • [Journal Article] Hydrogen Therapy Attenuates Irradiation-induced Lung Damage by Reducing Oxidative Stress2011

    • Author(s)
      Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H,(他7名)
    • Journal Title

      Am. J. Physiol. Lung Cell Mol. Physiol

      Volume: 301(4) Pages: L415-L426

    • DOI

      10.1152/ajplung.00008.2011

    • Peer Reviewed
  • [Journal Article] Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain2011

    • Author(s)
      Shinmura K, Tamaki K, Sano M, Nakashima-Kamimura N, Wolf AM, Amo T, Ohta S,(他5名)
    • Journal Title

      Circ Res

      Volume: 109(4) Pages: 396-406

    • DOI

      10.1161/CIRCRESAHA.111.243097

    • Peer Reviewed
  • [Journal Article] Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide2011

    • Author(s)
      Hanaoka T, Kamimura N, Yokota T, Takai S, Ohta S
    • Journal Title

      Med. Gas Res

      Volume: 1(1) Pages: 18

    • DOI

      10.1186/2045-9912-1-18

    • Peer Reviewed
  • [Journal Article] Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose-induced insulin secretion2011

    • Author(s)
      Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, (他11名)
    • Journal Title

      J Biol Chem

      Volume: 286(43) Pages: 37458-37469

    • DOI

      10.1074/jbc.M111.242651

    • Peer Reviewed
  • [Journal Article] Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects2011

    • Author(s)
      Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N
    • Journal Title

      Neurobiol. Dis

      Volume: 41(1) Pages: 111-118

    • DOI

      10.1016/j.nbd.2010.08.027

    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA alterations in colorectal cancer cell lines2011

    • Author(s)
      Chihara N, Amo T, Tokunaga A, Yuzuriha R, Wolf AM, Asoh S, Suzuki H, Uchida E, Ohta S
    • Journal Title

      J Nippon Med. Sch

      Volume: 78(1) Pages: 13-21

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/21389643

    • Peer Reviewed
  • [Journal Article] The 2011 Medical Molecular Hydrogen Symposium : An Inaugural Symposium of the Journal Medical Gas Research2011

    • Author(s)
      Ohta, S., Nakao, A., Ohno, K
    • Journal Title

      Med. Gas Res

      Volume: 1(1) Pages: 10

    • DOI

      10.1186/2045-9912-1-10

    • Peer Reviewed
  • [Journal Article] Recent Progress Toward Hydrogen Medicine : Potential of Molecular Hydrogen for Preventive and Therapeutic Applications2011

    • Author(s)
      Ohta S
    • Journal Title

      Curr. Pharm. Des

      Volume: 17(22) Pages: 2241-2252

    • DOI

      10.2174/138161211797052664

    • Peer Reviewed
  • [Presentation] Molecular hydrogen as a preventive and therapeutic medical gas : Initiation, development and potential of hydrogen medicine.2014

    • Author(s)
      Shigeo Ohta
    • Organizer
      1^<th> academic exchange and inaugural meeting on Hydrogen Molecule Biomedicine of the Hydrogen Molecular Biomedicine Professional Committee of Chinese Healthcare International Exchange Promotion Association
    • Place of Presentation
      Chinese
    • Year and Date
      2014-03-19
  • [Presentation] 水素医学研究update2014

    • Author(s)
      太田成男
    • Organizer
      2013第4回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-02-01
  • [Presentation] ミトコンドリアと生物活性物質との相互作用2013

    • Author(s)
      太田成男
    • Organizer
      京都-NPO法人国際医科学研究会第7回フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2013-12-01
  • [Presentation] 水素療法の神経系疾患に対する効果 : 基礎医学から治療および予防への臨床適用へ向かって2013

    • Author(s)
      太田成男
    • Organizer
      第31回日本神経治療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-11-22
  • [Presentation] Molecular Hydrogen is an Efficient Antioxidant Accompanied with Anti-inflammatory and Energy Metabolism-enhancing Roles. International Drug Discovery Science & Technology2013

    • Author(s)
      Shigeo Ohta
    • Organizer
      Therapy and EXPO Hainan International Convention and Exhibition Center
    • Place of Presentation
      IDDST Part of WGC China
    • Year and Date
      2013-11-15
  • [Presentation] Molecular Hydrogen has Potential for Preventive and Therapeutic Applications for Neurological Diseases2013

    • Author(s)
      Shigeo Ohta
    • Organizer
      International Drug Discovery Science & Technology
    • Place of Presentation
      Therapy and EXPO Hainan International Convention and Exhibition Center, MolMed Part of WGC China
    • Year and Date
      2013-11-15
  • [Presentation] 水素医学の展開 : 基礎医学から臨床実施へ第41回日本救急医学会総会2013

    • Author(s)
      太田成男
    • Organizer
      国際フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2013-10-21
  • [Presentation] ミトコンドリア機能と老化・疾患制御2013

    • Author(s)
      太田成男
    • Organizer
      第13回抗加齢医学会総会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2013-06-28
  • [Presentation] 水素医学の発展と健康への貢献2013

    • Author(s)
      太田成男
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
  • [Presentation] Hydrogen Medcine Group : Molecular Hydrogen Prevents Learning- and Memory-deficits Declined by Physical Restraint Stress2013

    • Author(s)
      Shigeo Ohta
    • Organizer
      AD/PD2013 (The 11^<th> International Conference On Alzheimer's & Parkinson's Diseases)
    • Place of Presentation
      Florence Italy
    • Year and Date
      2013-03-09
  • [Presentation] 水素医学の展開2012

    • Author(s)
      太田成男
    • Organizer
      日本NO学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-06-29
  • [Presentation] 水素医学の発展と健康への貢献2012

    • Author(s)
      太田成男
    • Organizer
      日本アンチエイジング歯科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-19
  • [Presentation] ミトコンドリアを維持し、増やすための生活の知恵2012

    • Author(s)
      太田成男
    • Organizer
      東洋はり医学会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-13
  • [Presentation] Recent progress toward hydrogen medicine2012

    • Author(s)
      Shigeo Ohta
    • Organizer
      International symposium of Mitochondrial biomedicine
    • Place of Presentation
      China
    • Year and Date
      2012-04-08
  • [Presentation] 健康・老化へのミトコンドリアの関与2012

    • Author(s)
      太田成男
    • Organizer
      第8回日本加圧トレーニング学会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-29
  • [Presentation] Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress for the therapeutic and preventive potential in lifestyle-related and mitochondrial diseases2011

    • Author(s)
      Shigeo Ohta
    • Organizer
      The eighth European Meeting on Mitochondrial Pathology(Euromit8)
    • Place of Presentation
      Spainスペイン
    • Year and Date
      20110620-23
  • [Presentation] ミトコンドリアが制御する健康・老化2011

    • Author(s)
      太田成男
    • Organizer
      第153回日本体力医学会関東会
    • Place of Presentation
      川崎
    • Year and Date
      2011-12-16
  • [Presentation] ミトコンドリアに起因する酸化ストレス2011

    • Author(s)
      太田成男
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山
    • Year and Date
      2011-12-10
  • [Presentation] ミトコンドリアと酸化ストレス2011

    • Author(s)
      太田成男
    • Organizer
      第23回分子糖尿病シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2011-11-26
  • [Presentation] 水素医学の進展 : 酸化ストレス軽減によるアポトーシス抑制のメカニズム2011

    • Author(s)
      太田成男
    • Organizer
      第20回日本Cell Death学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-30
  • [Book] 水素水とサビない身体2013

    • Author(s)
      太田成男
    • Total Pages
      186
    • Publisher
      小学館
  • [Book] NHKサイエンスZERO-ミトコンドリアの新常識2011

    • Author(s)
      太田成男
    • Total Pages
      128
    • Publisher
      NHK出版
  • [Remarks]

    • URL

      http://home.nms.ac.jp/ig/saiboseibutsu/index.html

  • [Patent(Industrial Property Rights)] 生体内の有害な活性酸素及び/またはフリーラジカル除去剤2012

    • Inventor(s)
      太田成男 室田渉
    • Industrial Property Rights Holder
      太田成男 室田渉
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      5106110
    • Acquisition Date
      2012-10-12
    • Overseas
  • [Patent(Industrial Property Rights)] ミトコンドリア病の予防又は治療薬2012

    • Inventor(s)
      太田成男
    • Industrial Property Rights Holder
      太田成男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      5028639
    • Acquisition Date
      2012-07-06
    • Overseas
  • [Patent(Industrial Property Rights)] 細胞死抑制活性強化タンパク質FNKを用いた脱毛の防止2006

    • Inventor(s)
      太田成男・麻生定光・上村尚美
    • Industrial Property Rights Holder
      太田成男・麻生定光・上村尚美
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      PCT/JP2006/305326
    • Filing Date
      2006-03-13
    • Overseas

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Published: 2015-06-25  

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