2013 Fiscal Year Final Research Report
The Influence of Gene and Environmental Interactions on Cognitive and Emotional Status in Older Adults
| Project/Area Number |
24653194
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical psychology
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| Research Institution | Osaka University |
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Principal Investigator |
GONDO Yasuyuki 大阪大学, 人間科学研究科, 准教授 (40250196)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIDE Kei 大阪大学, 大学院医学(系)研究科(研究院), 教授 (80393239)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 環境 / 遺伝 / 認知機能 / 感情 / 高齢期 |
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| Research Abstract |
This study was designed to evaluate the influence of gene-environment interactions on the cognitive function or emotional state in older adults. Parallel studies for the development of measurement systems of environmental condition and gene typing were performed.
Original methods to evaluate school achievement in childhood, job experience (complexity and stress) in midlife were developed. SNP typing for 6 candidate genes were also performed. A series of analyses to test the interaction of job complexity in midlife and each gene polymorphism on cognition were performed. Although the results showed a possibility of gene and environmental interaction in some genes (e.g., Klotho), the statistical power was too small to fully support this hypothesis. These results indicate that a more deliberate choice of control variables such as the medical condition is needed to clarify gene-environment interactions in a complex human life context.
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Research Products
(14 results)
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[Journal Article] Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity2013
Author(s)
Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, Todeschini M, Ogliari G, Imai E, Gondo Y, Hirose N, Mari D, Remuzzi G
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Journal Title
Age
Volume: 35(3)
Pages: 993-1005
Peer Reviewed
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[Journal Article] Sources of variation on the mini-mental state examination in a population-based sample of centenarians2013
Author(s)
Dai, T., Davey, A., Woodard, J. L., Miller, L. S., Gondo, Y., Kim, S.-H., & Poon, L. W
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Journal Title
Journal of the American Geriatrics Society
Volume: 61(8)
Pages: 1369-76
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[Journal Article] Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis2013
Author(s)
Davey, A., Dai, T., Woodard, J. L., Miller, L. S., Gondo, Y., Johnson, M. A., Poon, L. W
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Journal Title
Experimental Aging Research
Volume: 39(2)
Pages: 125-44
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[Journal Article] Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B2012
Author(s)
Congrains A, Kamide K, Oguro R, Yasuda O, Miyata K, Yamamoto E, Kawai T, Kusunoki H, Yamamoto H, Takeya Y, Yamamoto K, Onishi M, Sugimoto K, Katsuya T, Awata N, Ikebe K, Gondo Y, Oike Y, Ohishi M, Rakugi H
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Journal Title
Atherosclerosis
Volume: 220(2)
Pages: 449-55
Peer Reviewed
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[Presentation] Does Type of Activities Matter? Age and Gender Differences in Leisure Activities Among Japanese Older Adults2013
Author(s)
Ogawa M, Ishioka Y, Gondo Y, Kozono M, Masui Y, Nakagawa T, Tabuchi M , Tatsuhira Y, Ikebe K, Kamide K, Arai Y, Ishizaki T, & Takahashi R
Organizer
20th International Association of Gerontology and Geriatrics World Congress of Gerontology and Geriatrics
Place of Presentation
Korea
Year and Date
20130100
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[Presentation] 前期,後期高齢者の認知機能と仕事の複雑性との関連―SONIC研究の結果より―2013
Author(s)
石岡良子,権藤恭之,増井幸恵,稲垣宏樹,小川まどか,中川威,立平起子,神出計,池邉一典,新井康通,高橋龍太郎
Organizer
第55回老年社会科学大会
Place of Presentation
大阪
Year and Date
2013-06-06
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[Presentation] 高齢者の余暇活動と精神的健康の関連―SONIC研究における70歳調査結果より―2013
Author(s)
小園麻里菜,権藤恭之,小川まどか,石岡良子,増井幸恵,中川威,立平起子,神出計,池邉一典,新井康通,高橋龍太郎
Organizer
第55回老年社会科学大会
Place of Presentation
大阪
Year and Date
2013-06-05
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