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2013 Fiscal Year Final Research Report

Hemostatic mechanism and application ot endoscope of blood coagulation by low temperature atmospheric plasma

Research Project

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Project/Area Number 24654194
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Plasma science
Research InstitutionOsaka University

Principal Investigator

KITANO Katsuhisa  大阪大学, 工学(系)研究科(研究院), 准教授 (20379118)

Co-Investigator(Kenkyū-buntansha) KANEKO Kazuhiro  国立がん研究センター, 東病院, 科長 (30286786)
ITO Masaaki  国立がん研究センター, 東病院, 医長 (40312144)
Co-Investigator(Renkei-kenkyūsha) KUWATA Takeshi  国立がん研究センター, 東病院, 医長 (00327321)
KOMAI Yoshinobu  国立がん研究センター, 東病院, 医員 (50527067)
KOUSHI Kenichi  国立がん研究センター, 東病院, レジデント (70626829)
IKAWA Satoshi  大阪府立産業技術総合研究所, 主任研究員 (80393297)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords大気圧低温プラズマ / プラズマ医療 / 止血 / 血液凝固因子
Research Abstract

For blood coagulation by low temperature atmospheric plasma, plasma device for endoscope was developed and its hemostatic mechanism was evaluated. The lethality bleed from femoral vein of mouse was controlled with clarity. The bleed from internal organ with partial ablation was also controlled. By pathology assessment, no damege against body cell was seen. Because the shape of red blood cell was kept in blood clot, it seems that some of blood coagulation factor is triggered and plasma directly activate thrombin activation or fibrinogen degradation.

  • Research Products

    (20 results)

All 2014 2013 2012 Other

All Journal Article (6 results) Presentation (9 results) (of which Invited: 1 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Chemical Modification of Amino Acids by Atmospheric-Pressure Cold Plasma in Aqueous Solution2014

    • Author(s)
      Eisuke Takaia, Tsuyoshi Kitamuraa, Junpei Kuwabara, Satoshi Ikawa, Shunsuke Yoshizawa, Kentaro Shiraki, Hideya Kawasaki, Ryuichi Arakawa, and Katsuhisa Kitano
    • Journal Title

      Journal of Physics D : Applied Physics

      Volume: (accepted)

  • [Journal Article] Degeneration of amyloid-s fibrils caused by exposure to low-temperature atmospheric-pressure plasma in aqueous solution2014

    • Author(s)
      Eisuke Takai, Gai Ohashi, Tomonori Yoshida, Karin Margareta Sorgjerd, Tamotsu Zako, Mizuo Maeda, Katsuhisa Kitano and Kentaro Shiraki
    • Journal Title

      Appl. Phys. Lett

      Volume: 104 Pages: 023701

  • [Journal Article] Molecular mechanism of plasma sterilization in solution with the reduced pH method : importance of permeation of HOO radicals into the cell membrane2013

    • Author(s)
      Eisuke Takai, Satoshi Ikawa, Katsuhisa Kitano, Junpei Kuwabara, Kentaro Shiraki
    • Journal Title

      Journal of Physics D : Applied Physics

      Volume: 46 Pages: 295402

  • [Journal Article] Free radicals induced in aqueous solution by non-contact atmospheric-pressure cold plasma2012

    • Author(s)
      A. Tani, Y. Ono, S. Fukui, S. Ikawa, K. Kitano
    • Journal Title

      Appl. Phys. Lett

      Volume: 100 Pages: 254103

  • [Journal Article] Extracellular matrix patterning for cell alignment by atmospheric pressure plasma jets2012

    • Author(s)
      A. Ando, T. Asano, A. Sayed, R. Tero, K. Kitano, T. Urisu, S. Hamaguchi
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 51 Pages: 036201

  • [Journal Article] Protein Inactivation by Low-Temperature Atmospheric Pressure Plasma in Aqueous Solution2012

    • Author(s)
      Eisuke Takai, Katsuhisa Kitano, Junpei Kuwabara, Kentaro Shiraki
    • Journal Title

      Plasma Processes and Polymers

      Volume: 9 Pages: 77-82

  • [Presentation] Cryopreservation of the plasma treated water for disinfection treatment in dental and surgical therapies based on the reduced pH method2014

    • Author(s)
      Katsuhisa Kitano, Satoshi Ikawa, Atsushi Tani, Yoichi Nakashima, Tomoko Ohshima, Hiromitsu Yamazaki, Emi Usui, Yasuko Momoi
    • Organizer
      International Symposium on Non-equilibrium Plasma and Complex-System Sciences (IS-NPCS)
    • Place of Presentation
      Osaka University
    • Year and Date
      20140226-28
    • Invited
  • [Presentation] Strong bactericidal activity of the plasma treated water for medical application based on the reduced pH method2014

    • Author(s)
      Katsuhisa Kitano, Satoshi Ikawa, Atsushi Tani, Yoichi Nakashima, Tomoko Ohshima
    • Organizer
      8th International Conference on Reactive Plasmas 31st Symposium on Plasma Processing
    • Place of Presentation
      Fukuoka
    • Year and Date
      20140203-07
  • [Presentation] Freezing preservation of the plasma treated water for disinfection treatment in dental and surgical therapies based on the reduced pH method2013

    • Author(s)
      Katsuhisa Kitano, Satoshi Ikawa, Atsushi Tani, Yoichi Nakashima, Hiromitsu Yamazaki, Tomoko Ohshima, Kazuhiro Kaneko, Masaaki Ito, Takeshi Kuwata, Atsushi Yagishita
    • Organizer
      21st International Symposium on Plasma Chemistry (ISPC 21)
    • Place of Presentation
      Cairns Convention Centre, Queensland, Australia
    • Year and Date
      20130804-09
  • [Presentation] Plasma treated water with the reduced pH method for effective disinfection in dental and surgical treatment2013

    • Author(s)
      K. Kitano, S. Ikawa, A. Tani, H. Yamazaki, T. Oshima, E. Usui, Y. Momoi, K. Kaneko, M. Ito, T. Kuwata, A. Yagishita
    • Organizer
      The 12th Asia Pacific Physics Conference of AAPPS (APPC-12)
    • Place of Presentation
      Makuhari, Chiba
    • Year and Date
      20130714-19
  • [Presentation] Plasma photonics2013

    • Author(s)
      K. Kitano
    • Organizer
      Fundamentals and Applications of Nanophotonics, Photovoltaics and Bio-photonics
    • Place of Presentation
      Morocco Optics and Photonics Center, MAScIR, Rabat, Morocco
    • Year and Date
      20130307-08
  • [Presentation] Toward medical applications of atmospheric pressure plasmas with room temperature ~ Physics, Chemistry, Biochemistry, Molecular biology, Medicine ~2013

    • Author(s)
      K. Kitano
    • Organizer
      2013 Japan-Taiwan Symposium on Polyscale Technologies for Biomedical Engineering and Environmental Sciences (PT-BMES 2013)
    • Place of Presentation
      Plenary
    • Year and Date
      20130000
  • [Presentation] The reduced pH method with indirect plasma for safe and effective disinfection in dentistry and surgery2012

    • Author(s)
      K. Kitano, S. Ikawa, A. Tani, H. Yamazaki, T. Ohshima, K. Kaneko, M. Ito, T. Kuwata, A. Yagishita
    • Organizer
      The 39th IEEE International Conference on Plasma Science (ICOPS)
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      20120708-12
  • [Presentation] Innovative disinfection for dental and surgical therapies combined with the plasma treated water and the reduced pH method2012

    • Author(s)
      K. Kitano, S. Ikawa, A. Tani, H. Yamazaki, T. Ohshima, K. Kaneko, M. Ito, T. Kuwata, Yagishita
    • Organizer
      4th International Conference on Plasma Medicine
    • Place of Presentation
      Orleans, France
    • Year and Date
      20120617-21
  • [Presentation] Toward Medical Applications of Atmospheric Pressure Plasmas ~ Physics, Chemistry, Biochemistry, Molecular biology, Medicine~2012

    • Author(s)
      K.Kitano
    • Organizer
      IUMRS-ICEM2012
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-09-27
  • [Book] 「プラズマジェットを用いた殺菌メカニズムと消毒応用」、静電気学会誌、37、32013

    • Author(s)
      北野勝久、井川聡、谷篤史、大島朋子
    • Total Pages
      112-116
  • [Book] 「プラズマプロセスの新展開 医療応用の可能性」,クリーンテクノロジー2013

    • Author(s)
      北野勝久、谷篤史、井川聡、大島朋子
    • Publisher
      日本工業出版
  • [Book] 冷たいプラズマを用いた液中誘起化学反応のバイオ応用~重合から殺菌まで~, 化学と教育,60巻9号2012

    • Author(s)
      北野勝久
    • Total Pages
      380
  • [Remarks]

    • URL

      http://www.plasmabio.com/

  • [Patent(Industrial Property Rights)] Plasma producing apparatus and method of plasma production2012

    • Inventor(s)
      北野勝久、浜口智志、青木裕紀
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      米国登録
    • Industrial Property Number
      US8232729
    • Acquisition Date
      2012-07-31
    • Overseas

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Published: 2015-06-25   Modified: 2015-07-02  

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