2013 Fiscal Year Final Research Report
Development of effective nano-sizing method for dispersible additive-free poorly-water-soluble drugs and its application
| Project/Area Number |
24655113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
ARITA TOSHIHIKO 東北大学, 多元物質科学研究所, 助教 (50423033)
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| Co-Investigator(Kenkyū-buntansha) |
YABU Hiroshi 東北大学, 多元物質科学研究所, 准教授 (40396255)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ナノ医薬品材料 / 超微粒子 / 有機ナノ結晶 / コロイド / 結晶成長 / 過飽和溶解 / 固体分散 |
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| Research Abstract |
This study aimed to solve most of problems of poorly-water-soluble drugs (acceleration of dissolution, reduction of additives, suppression of aggregation and improvement of solid dispersion) by additive-free nano-sizing. By using esculent carbon dioxide as the solvent and applying triboelectric charge as the dispersion force, additive-free nano-sizing (less than 100nm diameter) of poorly-water soluble drugs was achieved. As the result, above mentioned problems have been solved, in addition, supersaturated dissolution (10% excess dissolution to the saturated concentration) of the nano-sized drugs has been found.
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[Book] 高圧力の科学と技術 特集:高圧力技術によるナノマテリアル創製研究の最前線 「超臨界水熱プロセスによるナノ粒子の合成とハイブリッド化―粒子表面改質による相反機能材料開発―」2012
Author(s)
阿尻雅文, 新井智宏, 石川佳澄, 上野真孝, 上田正孝, 岡田拓也, 大島英紀, 中川孝行, 福島敬二, 前田重之, 宮田建治, 森下丈弘, 山縣利貴, 高見誠一, 青木宣明, 有田稔彦, 他
Total Pages
89-96
Publisher
高圧学会
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