Mechanism of extraordinary heat production by Pseudomonas putida.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24655148
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemistry related to living body
• Research Institution: Daiichi University, College of Pharmaceutical Sciences (2014); Tokyo Institute of Technology (2012-2013)
• Principal Investigator: TABATA Kenji 第一薬科大学, 薬学部, 准教授 (80312263)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 微生物 / エネルギー代謝

Outline of Final Research Achievements

Pseudomonas putida TK1401 produces extraordinary heat by growth-independent reaction. In this study, we investigated the mechanism of the growth-independent reaction. A result of differential display, amounts of Succinyl-CoA synthetase (SCS) and ornithine carbamoyl transferase (OCT) were increased at suboptimal growth temperature. SCS catalyzes a production of ATP. On the other hand, OCT is a protein which relates ATP consumption. Therefore, SCS and OCT could be involved in the growth-independent reaction of P. putida KT1401.

Free Research Field

生物無機化学