2013 Fiscal Year Final Research Report
Formulation of multifunctional bio-interface that aims at application to artificial blood vessel
| Project/Area Number |
24656404
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural/Functional materials
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBATAKE Eiri 東京工業大学, 総合理工学研究科, 教授 (00225484)
MATSUMOTO Hidetoshi 東京工業大学, 理工学研究科, 准教授 (40345393)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 人工血管 / ePTFE / 表面処理 / コラーゲン / バイオインターフェース |
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| Research Abstract |
It aimed to achieve an artificial blood vessel of 5mm or less in inside diameter. By using a sheet of expanded polytetrafluoroethylene that was a model material of the artificial blood vessel, the improvement of adhesion with collagen that was an intermediate material for adhesion with the endothelial cell was attempted. The anchor effect by cutting the fibril by the surface treatment and making collagen easy to invade the inside of film was important in the adhesion. An increase in the interaction by the introduction of the polarity functional groups with oxygen and an increase in carbon ratio were also important. When the collagen was processed by the ion beam, the composition of amino-acid has changed to remove the amino-acids of weak bonding from the protein. Though the endothelial cell is easily bonded to collagen, it is considered that the adhesion of platelet to collagen changes by the change in the amino-acid composition as an increase in the amount of ion beam irradiation.
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