2012 Fiscal Year Final Research Report
Identification of muscle support cells generated during muscledifferentiation
| Project/Area Number |
24657154
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
SEHARA Atsuko 京都大学, 再生医科学研究所, 教授 (60209038)
|
|---|
| Project Period (FY) |
2012
|
| Keywords | 筋形成 / 筋衛星細胞 / 幹細胞 / 細胞外基質 / 細胞間相互作用 |
|---|
| Research Abstract |
Mechanisms of myogenesis induced by myogenin have been elusive. Wehave succeeded to isolate myogenin-negative cells from differentiating myoblast C2C12cells, and have found that those ells express sets of genes different from myogeninpositive cells by microarray. One of these genes is expressed in regions adjacent tomuscle, and knockdown of this gene significantly affected myogenesis and enhancedapoptosis in zebrafish, supporting an idea that this gene and cells expressing this geneare involved in the maintenance or survival of muscle cells. Whether these cells aregenerated from muscle satellite cells was examined.
|
